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Is Bipolar Disorder Hereditary?

Is Bipolar Disorder Hereditary?

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When we can see our family in ourselves, it’s easy to wonder what else we might have inherited from them, particularly when it comes to our mental health.

We may see them managing their condition and wonder if we’ll need to do the same. Especially when dealing with a complex and often misunderstood diagnosis like bipolar disorder, the looming question of whether it’s been passed onto you or not can be unsettling.

When armed with knowledge and proactive strategies, it doesn’t have to be.

In this detailed article, we’ll uncover the potential role genes play, the other risk factors, and the implications of both.

Genetics’ role in bipolar disorder

Like many mental health conditions, bipolar disorder results from a mix of genetic and environmental influences. The fact that the biological children or siblings of those with bipolar disorder are much more likely to develop it themselves suggests there’s a genetically linked component to the condition.

However, this doesn't mean bipolar disorder is directly ‘inherited’ in the way eye color or hair texture might be. Instead, what is passed down are genetic variants that can make you more predisposed to developing the disorder.

The likelihood of inheriting bipolar disorder

The average risk for bipolar disorder has typically been reported to be around 1%, though recent estimates are as high as 4%. However, having a ​​first-degree relative, such as a biological parent or sibling, with the condition can increase your risk.

According to the National Institute of Mental Health, having one parent with bipolar disorder increases one’s risk by a range of 15% to 30%. When both parents are affected by the disorder, the risk increases to a range of 50% to 75%.

This means that it is fairly heritable, but bipolar disorder can also be influenced by other risk factors, which is why people can be diagnosed without having a family history.

​​If you have a genetic predisposition, it doesn't automatically mean you will develop the condition; however, having that family history does make it essential for you to watch for the symptoms of bipolar disorder so you can manage it if it does develop.

Can bipolar disorder skip a generation?

It could look like the disorder skipped a generation because not everyone who carries the genes will show symptoms. The genetic expression or combination of genes that contribute to the disorder could remain dormant or not expressed.

What this means: Theoretically, a person can have a genetic predisposition to bipolar disorder without it seeming like they have any affected relatives in their immediate family.

Additionally, bipolar disorder can be misdiagnosed, as its symptoms overlap with other mental health conditions, complicating its diagnosis early in its course, which is also why it could initially appear to skip a generation.

Is there a bipolar gene?

The short answer is no. Even though researchers have found some specific genes that might be involved, there's no single ‘bipolar gene’ responsible for the disorder.

The bottom line: Its development stems from a complex interplay between numerous genes and environmental influences.

A combination of minor variations in multiple genes is believed to contribute to an individual's overall risk.

Close-up of redhead bearded man in white shirt looking stressed while sitting at a table.

Other risk factors

There are a broad set of risk factors that go beyond genetics. The genetic aspects of bipolar disorder don't act in isolation — they’re constantly interacting with many environmental elements and other neurological factors. 

Brain injury or structural factors

A history of severe head injury has been associated with an increased risk of developing bipolar disorder, suggesting that brain structure or brain function abnormalities might play a role in the disorder's onset.

Also, brain-related conditions, such as epilepsy, often occur alongside bipolar disorder and can be passed down in families.

Environmental factors

Our genes can interact with the impacts of our environment in ways that can affect our mental health. People might inherit genes that make them more likely to be affected by stress or more prone to substance misuse.

This can make it hard to predict who will develop bipolar disorder, but it also provides avenues for preventing expression or minimizing the impact of the disorder by considering environmental factors.

Traumatic events
Experiencing severe trauma can affect one’s mental health.
Traumatic life events, particularly in early life, can have a gene-environment interaction, influencing changes in the structure and function of the brain over time.

Research suggests a connection between childhood trauma and experiences of bipolar disorder that are early onset and more severe later in life.

What you can do: Engaging in therapy, especially cognitive behavioral therapy (CBT) or dialectical behavior therapy (DBT), provides strategies for coping with emotional distress and trauma, helping lessen the impact of this type of environmental factor.

Substance use
Substance misuse and bipolar disorder often occur together, influenced by both genetics and environment. The relationship between them is two-way: substance use can increase the risk of developing bipolar disorder and can also result from it.

Genetic factors linked to the disorder might also make a person more prone to substance use disorders, and similarly, genes associated with addiction can increase the risk of bipolar disorder.


What you can do: If you have a family history of bipolar disorder or have been diagnosed, you should exercise caution regarding the use of substances. Support groups or therapy can help with coping with the urge to use substances.

Poor sleep
If your sleep patterns are off, it could be an early indication of emerging or destabilizing bipolar disorder.

While sleep disturbances are features of bipolar disorder, they may also contribute to its onset, especially when considering genetic predispositions.

What you can do: Keeping a regular sleep schedule is an important part of managing the condition.

Tense relationships
Social relationships can have a profound impact on mental health, acting as either sources of support or stress. Examples of the latter include:

  • Being in a rocky relationship, which could make the ups and downs of bipolar disorder even worse.
  • Workplace conflicts, which could trigger stress.
  •  Arguments or a lack of understanding within a family, which could serve as both a stressor and trigger. 

While these stressful social interactions don’t directly cause bipolar disorder, the stress could make someone with the disorder more vulnerable to experiencing emotional highs and lows and influence its manifestation and severity.

What you can do: Those at risk or in the process of managing the condition should prioritize supportive, relaxed social environments.

Black young man with hand on chin looking confident and thoughtful.

Understanding and managing bipolar risk

Digging into how genetic and environmental factors play a role in bipolar disorder gives you a chance to take control. Knowing if you have a hereditary risk of bipolar disorder can be crucial in identifying and managing it early. Early detection allows for both preventive steps and lifestyle changes that may make symptoms less intense and episodes easier to handle, or could potentially delay the onset of the disorder.

Explore more: 10 Things to Know About Bipolar Disorder

Being aware of the genetic risk factors of bipolar disorder also sets you up to take a proactive approach to mental health, including going to therapy, participating in routine screenings, and adopting healthy habits like managing stress and exercising regularly. Being hands-on early helps manage the potential impact of bipolar disorder symptoms and empowers you to take control of your mental wellness, enhancing your overall well-being.

Whether you’ve been diagnosed or think there’s a likelihood you could develop bipolar disorder due to family history, personalized care is of the utmost importance.

Recognizing that your mental health experiences are unique, we're here to support you with flexibility, compassion, and the specialized care you deserve. We offer online access to licensed therapists and prescribers, all from the comfort of your own home. Our highly rated mental health professionals can help you with concerns about hereditary risks, understanding the signs and symptoms of bipolar, coping strategies for environmental stressors, or bipolar symptom management.

If you or a loved one have concerns about bipolar disorder, including its potential hereditary factors, consider reaching out to one of Cerebral’s mental health specialists to begin the conversation on your terms.


Images via shurkin_son, drobotdean, and andreas on Freepik.

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Apr 9, 2024
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Additionally, we have a large network of top-tier licensed prescribers, allowing you to also manage your bipolar medication online from one central place under one affordable subscription with free expedited shipping. Want to give Cerebral a try? Schedule your first session today. Images by freepik and freepik on Freepik. The information in this blog is provided as a general educational resource only, and is not to be used or relied on for any diagnostic or treatment purpose. This information should not be used as a substitute for professional diagnosis and treatment and does not create any patient-physician relationship between you and Cerebral. Please consult your health care provider before making any health care decisions or to get guidance about a specific medical condition.
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Bipolar Disorder
Effects of Marijuana on Bipolar Disorder
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Cognitive effects of marijuana use One of the many concerning effects of marijuana use is its impact on cognitive functions like memory and attention, which can already be affected by bipolar disorder’s symptoms. Use can also influence coordination and reflexes. These cognitive effects can exacerbate the challenges that bipolar disorder’s shifts in thinking and daily functioning present, including: Declined memory: Research indicates that marijuana use, particularly long-term or heavy use, can impair both short- and long-term memory.  Reduced attention and concentration: Marijuana can also affect an individual’s ability to focus, pay attention, and process information efficiently.  The effects of marijuana also extend to psychomotor skills, impairing coordination and slowing reflexes. For someone with bipolar disorder, these effects could make managing medication schedules more difficult, present challenges with school or work tasks, and increase their risk of accidents and injuries. Marijuana interferes with medication Individuals with bipolar disorder often rely on mood stabilizers like lithium or antipsychotics, which are processed by liver enzymes. The active compounds in marijuana, THC and cannabidiol (CBD), can interfere with these enzymes, potentially causing medications to reach dangerously high levels or fluctuate unpredictably in the bloodstream. What this means: Elevated levels of mood stabilizers might lead to toxicity, while insufficient levels may fail to prevent mood swings. Additionally, marijuana use can intensify the sedative effects of bipolar medications, further impairing daily functioning. To help avoid safety issues and unpredictable outcomes, individuals with bipolar disorder should discuss any marijuana use with their healthcare provider. Marijuana use can lead to symptoms of psychosis Some bipolar individuals are already at risk of experiencing psychosis. THC, the active component in marijuana, could trigger psychotic symptoms by interacting with the brain's cannabinoid receptors, affecting mood, perception, and cognition. People with bipolar disorder have brain chemistry and mood regulation mechanisms that are already affected. Introducing THC can disrupt neural pathways further, increasing the risk of experiencing psychotic episodes for some. For those who experience psychosis, symptoms such as hallucinations, delusions, or disorganized thinking could worsen. The association between marijuana use and psychosis is particularly significant for those with a family history of psychotic disorders. Explore more: What You Should Know About Bipolar Psychosis It can increase the frequency of bipolar episodes Marijuana's impact on the brain can destabilize a person's mood, potentially triggering more frequent and intense episodes. THC can disturb the brain's natural mood regulation by affecting neurotransmitters like dopamine and serotonin. This disruption can lead to more frequent and severe mood swings, amplifying the underlying mood instability associated with bipolar disorder. By affecting the brain’s natural mood regulators, marijuana can lead individuals to cycle back and forth between mania and depression, which can make it challenging to manage bipolar disorder. The bottom line: Marijuana's effects can make it more difficult to maintain emotional stability. It may increase the risk of suicide Marijuana use could worsen the condition by increasing suicidal thoughts and behaviors. Bipolar disorder inherently raises the risk of suicide due to its severe mood fluctuations. When marijuana is used, it can intensify depressive symptoms, making the lows feel even more profound and unbearable. Why this is important: Major depressive episodes can be strongly linked to suicidal thoughts and behaviors. Reliance on the substance for relief could also potentially lead to a vicious cycle of dependency and heightened despair and hopelessness, thereby elevating the risk of suicide. Professional guidance is vital for managing the condition safely, and self-medication practices that could lead to more severe outcomes should be avoided. Other effects of marijuana use While marijuana can be regarded for its therapeutic properties, it's important to recognize that regular use has its own set of health risks, too. Specific examples of how marijuana can negatively impact someone's health include: Cardiovascular health: Marijuana use increases heart rate and blood pressure shortly after use, which can be particularly concerning for individuals with pre-existing heart conditions. Over time, this elevated strain on the cardiovascular system could increase the risk of heart-related issues. Respiratory problems: Smoking weed can harm the respiratory system, similar to how smoking cigarettes does. Regular marijuana smokers may experience chronic bronchitis, lung irritation, and an increased risk of respiratory infections. It's critical to consider the added burden of managing a physical health complication on top of a mental health condition. Can marijuana increase the chance of becoming bipolar? While marijuana use has not been definitively linked to causing bipolar disorder, it can potentially act as a trigger for bipolar episodes due to its impact on the developing brain. Studies show that using the drug can increase your chance of developing bipolar disorder as well as producing an earlier onset of the condition.  Research published in JAMA Psychiatry found that marijuana use raises the risk of developing bipolar disorder, and its use also increases the risk of bipolar psychosis even more.  A study in the Journal of Affective Disorders suggested that individuals who use marijuana may experience the onset of bipolar symptoms earlier than those who do not use the drug.  Research in the American Journal of Psychiatry indicates that individuals with certain genetic markers for bipolar disorder are more susceptible to the mood-altering effects of THC, suggesting a genetic basis for the adverse outcomes observed in some cases. Given the potential for the drug to interfere with bipolar disorder management, a careful and individualized approach to treatment and counseling is warranted. For individuals with a genetic predisposition to mental health conditions like bipolar, marijuana use should be approached with extreme caution. How bipolar disorder is treated Treating this disorder requires a multifaceted approach that typically involves a combination of medication, therapy, and lifestyle adjustments.  Medication Bipolar disorder treatment typically includes mood-stabilizing medication tailored to each patient's unique needs to manage the cycles of highs and lows. Lithium and other anticonvulsants are common in stabilizing moods. Antipsychotics may be prescribed for episodes. What works best can differ between people, but a licensed prescriber can help you develop a medication regimen that alleviates your bipolar symptoms.  Therapy In-person or online therapy can help you recognize triggers and develop coping mechanisms without relying on substances like marijuana. It also supports the development of a healthy daily routine, which is crucial for managing the mood swings common in bipolar disorder. Why this is important: Lowering the intensity of mood episodes could help reduce the desire to look to alternatives for symptom relief.  Lifestyle adjustments Equally important are lifestyle adjustments that promote health and balance while managing bipolar symptoms. This can include having a set daily routine, getting regular exercise, eating a balanced diet, and getting enough sleep. Since substance use can be a trigger, avoiding or limiting use may be vital to maintaining your mental and physical well-being. The goal of treatment is to manage symptoms, reduce the frequency and intensity of mood swings, and help you lead a more stable and fulfilling life. Learn more: Treatment Options for Bipolar Disorder The risks outweigh potential benefits Marijuana use complicates an already complex illness and treatment process. It can potentially lead to worse bipolar symptoms, medication issues, and an increased risk of suicide, psychosis, and other health problems. If you haven’t been diagnosed but are wondering about your mental health status, the use of marijuana could potentially act as a catalyst, increasing the chances of the disorder’s onset. People with bipolar are already at a higher risk of developing substance use disorder due to their brain's reward system's altered functioning. Adding marijuana into the mix can further increase the likelihood of developing this disorder. The most important action you can take is to seek professional advice and have an open, honest conversation about the risks of marijuana use. With that knowledge, you can make informed decisions that lead to long-term mental wellness and stability. If you’re managing bipolar disorder and weighing the effects of marijuana use, our care team — including licensed prescribers, online therapists, and care counselors — will work with you to address your mental health needs and substance use concerns. With Cerebral, you can get personalized therapy and work with a licensed professional to manage your medication all from the comfort and privacy of your home. Images by freepik, freepik, and freepik on Freepik. The information in this blog is provided as a general educational resource only, and is not to be used or relied on for any diagnostic or treatment purpose. This information should not be used as a substitute for professional diagnosis and treatment and does not create any patient-physician relationship between you and Cerebral. Please consult your health care provider before making any health care decisions or to get guidance about a specific medical condition.
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Apr 3, 2024
Bipolar Disorder
The Differences Between Bipolar Disorder and ADHD
The Differences Between Bipolar Disorder and ADHD Understanding mental health conditions is crucial, especially when disorders can share similar symptoms yet require different approaches for management. Bipolar disorder and ADHD are two conditions that can look like one another. In this explanatory guide, we'll unravel the nuances of these conditions to help you distinguish between them. What is bipolar disorder? Bipolar disorder is a complex mental health condition characterized by extreme shifts in mood, energy levels, thinking, and the ability to function. Previously known as manic depression, bipolar disorder can vary from person to person in its severity and combination of symptoms. These shifts are called mood episodes and are distinctly different from the person's usual state. Types of bipolar disorder Bipolar disorder is divided into several subtypes, with the most common being bipolar I and bipolar II, along with cyclothymia, which is a milder form. Bipolar I disorder involves episodes of severe mania that last at least 1 week, sometimes requiring hospitalization. There may also be depressive episodes, typically lasting 2 weeks or more. Bipolar II disorder is characterized by a pattern of depressive episodes and hypomanic episodes, which are less severe than full-blown mania. Cyclothymia (also known as cyclothymic disorder) features numerous periods of hypomanic symptoms and depressive symptoms that last for at least 2 years, with no more than 2 months of stable moods in between. Bipolar symptoms  When a person is experiencing a manic episode, they may feel euphoric and full of energy. 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Therapy, particularly cognitive behavioral therapy (CBT), can help individuals understand and manage their condition's social and psychological aspects. Explore more: Treatment Options for Bipolar Disorder What is ADHD? Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects the ability to pay attention and control impulsive behaviors. It can also cause hyperactivity, which can be challenging to manage. ADHD symptoms The symptoms of ADHD are typically grouped into two categories: inattention and hyperactivity-impulsivity. These symptoms are often present in childhood and can persist into adulthood. Manic symptoms can look like ADHD because they include: High physical and mental energy levels that manifest in ADHD-like restlessness Rapid speech and thought Racing ideas and constant activity Trouble concentrating and/or remembering plans, to-do’s, and commitments  Depressive symptoms can also mimic these symptoms of ADHD: Difficulties with focus and attention due to a depressed mood Lack of energy, leading to reduced activity both physically and mentally Low self-esteem that affects motivation and confidence ADHD treatment options ADHD treatment typically involves a multifaceted approach, including medication, lifestyle modifications, and counseling. When exploring medication options for ADHD, it's essential to engage in a thorough discussion with healthcare providers about the full spectrum of treatment possibilities that might suit your needs. One avenue in managing ADHD symptoms involves non-stimulant medication options. These alternatives work differently from stimulants, focusing on increasing levels of certain neurotransmitters in the brain. Behavior therapy, family therapy, and support groups can benefit someone diagnosed with ADHD and their family members. These therapies can help a person with ADHD implement organizational habits, develop social skills, and manage disruptive behaviors. Key differences between bipolar and ADHD While there are similarities between ADHD and bipolar disorder, there are distinct differences that can help distinguish one from the other, including: Age of onset: ADHD typically presents in childhood, with symptoms appearing before the age of 12. On the other hand, bipolar disorder often develops in late adolescence or early adulthood. Nature of symptoms: The symptoms of bipolar disorder are characterized by distinct cyclical periods of mania and depression that can last for weeks or longer. In contrast, ADHD symptoms tend to be more chronic and less episodic. However, they may fluctuate in intensity. Triggers: Environmental triggers are more commonly linked to mood episodes in bipolar disorder, whereas external situations don’t impact symptoms of ADHD. Diagnosing ADHD vs. bipolar disorder Proper diagnosis of either disorder helps select a course of action for managing symptoms. However, due to the complexity of symptoms and their potential overlap, making an ADHD or bipolar diagnosis can be challenging. It often involves: A comprehensive assessment of symptoms and family history The ruling out of other conditions that could be causing similar symptoms Psychological and cognitive testing to evaluate cognitive and behavioral patterns Can you have ADHD and bipolar disorder? Yes, ADHD and bipolar disorder can occur together, particularly in adults. This presents a unique diagnostic and treatment challenge, as both conditions may need to be addressed simultaneously. Management strategies include: Careful consideration of medication to avoid making symptoms worse Education and regular monitoring to manage symptoms  A collaborative approach between the patient and any medical and/or mental health professionals involved Seeking treatment for bipolar and/or ADHD If you suspect you have either or both conditions, seeking professional help is important, as early diagnosis and intervention can significantly improve outcomes. With Cerebral’s online therapy and medication management services, you can get personalized treatment from the comfort of your home. Our highly-rated mental health professionals will help you understand your condition, implement coping strategies, develop a treatment plan, and provide the support you deserve through all the phases of treatment. Images via DC Studio and pressfoto on Freepik. The information in this blog is provided as a general educational resource only, and is not to be used or relied on for any diagnostic or treatment purpose. This information should not be used as a substitute for professional diagnosis and treatment and does not create any patient-physician relationship between you and Cerebral. Please consult your health care provider before making any health care decisions or to get guidance about a specific medical condition.
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